| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968186 | Vaccine | 2011 | 10 Pages |
Abstract
⺠T-cell immunity is required to contain HSV infection. ⺠HSV vaccines tested thus far elicited predominantly antibody response. ⺠A candidate vaccine of 32 HSV-2 peptides complexed with recombinant human heat shock protein Hsc70 was administered to HSV-2 seropositive healthy adults in a Phase 1 study. ⺠The vaccine elicited a significant CD4+ and CD8+ T cell response and was well tolerated.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Anna Wald, David M. Koelle, Kenneth Fife, Terri Warren, Kenneth LeClair, Roman M. Chicz, Stephen Monks, Daniel L. Levey, Cristina Musselli, Pramod K. Srivastava,