| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968253 | Vaccine | 2012 | 7 Pages |
Abstract
⺠A PCP-consensus antigen was designed based on the physicochemical properties of 671 unique DENV sequences. ⺠Two regions of maximum variability were adjusted to obtain recognition by antibodies against DENV-4. ⺠The optimized protein was recognized by polyclonal antibodies against all four DENV serotypes. ⺠Two amino acids in the N-terminus were essential for good binding to all four serotype specific antibodies.
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Authors
David M. Bowen, Jessica A. Lewis, Wenzhe Lu, Catherine H. Schein,