Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination

Article ID	Journal	Published Year	Pages	File Type
10968264	Vaccine	2011	13 Pages	PDF

Abstract

âº We studied 801 SNPs in 56 genes, in a cohort of 745 MMR-vaccinated schoolchildren. âº We found 48 significant associations with variations in vaccine immune responses. âº We replicated an association of IL12B rs3212227 with variations in humoral immunity. âº We replicated two IL10 and IL2 SNP associations with cellular immunity variations. âº Single SNP and haplotype analysis revealed IL7R associations with vaccine immunity.

Keywords

Cytokine Immunity Haplotypes Measles vaccine Single nucleotide polymorphisms Cytokine receptor

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination

Authors

Iana H. Haralambieva, Inna G. Ovsyannikova, Richard B. Kennedy, Robert A. Vierkant, V. Shane Pankratz, Robert M. Jacobson, Gregory A. Poland,