| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968284 | Vaccine | 2011 | 10 Pages |
Abstract
⺠Investigation of the reactivity of a monoclonal antibody against continuous peptides from the dermonecrotic protein from Loxosceles intermedia (LiD1). ⺠Identification of four LiD1 peptide mimotopes using a phage-display approach. ⺠The putative epitope region (residues C197, Y224, W225, T226, D228, K229, R230, T232 and Y248 of LiD1) recognized by LimAb7 were predicted using MIMOP, a bioinformatic tool. ⺠Neutralization of the biological effects induced by Loxosceles intermedia spider venom by antibodies anti-mimotope peptide. ⺠Synthetic immunogens may be promising candidates for alternative therapeutic serum development.
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Authors
J. de Moura, L. Felicori, V. Moreau, G. Guimarães, C. Dias-Lopes, L. Molina, L.M. Alvarenga, P. Fernandes, F. Frézard, R.R. Ribeiro, C. Fleury, C. Nguyen, F. Molina, C. Granier, C. Chávez-Olórtegui,