Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10968286 | Vaccine | 2011 | 10 Pages |
Abstract
⺠To gain insight into differences in the serotype-specific host response to pneumococcal in the lungs, we compared the effect of intranasal infection with a serotype 3 and a serotype 8 strain of pneumococcus on gene expression in the lungs of mice. ⺠Both strains induced expression of interferon-gamma-inducible genes in an inoculum dependent manner. ⺠In a model in which the lung bacterial burden was similar and death occurred by 72 h after infection, serotype 3-infected mice exhibited a more exuberant inflammatory response and higher levels of interferon-gamma-inducible gene expression than serotype 8-infected mice. ⺠The virulence of serotype 3, but not serotype 8 was reduced in CXCR3-deficient mice. ⺠Serotype 3-infected CXCR3-deficient mice recruited more macrophages to their lungs and had a less exuberant lung inflammatory response than wild type mice.
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Authors
Beza Seyoum, Masahide Yano, Liise-anne Pirofski,