Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10968352 | Vaccine | 2012 | 8 Pages |
Abstract
⺠Immunization with naturally evolving env genes, given sequentially, is promising. ⺠Motif-optimized env sequences were superior to wild type for neutralizing antibodies. ⺠Simultaneous boosting with DNA and protein at different sites enhanced antibodies. ⺠Antibodies that neutralized heterologous HIV-1 isolates were obtained in rabbits.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Franco Pissani, Delphine C. Malherbe, Harlan Robins, Victor R. DeFilippis, Byung Park, George Sellhorn, Leonidas Stamatatos, Julie Overbaugh, Nancy L. Haigwood,