Article ID Journal Published Year Pages File Type
10968384 Vaccine 2012 10 Pages PDF
Abstract
► We detected specific CD8+ T cells to Trypanosoma cruzi after infection. ► Specific CD8+ T cells are primed in the draining lymph nodes. ► We administered the functional antagonist of S1P1 (FTY-720) prior to infection. ► FTY-720 administration reduced re-circulation of specific CD8+ T cells to the spleen. ► FTY-720 administration reduced immunity to infection and genetic vaccination.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi
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