| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968511 | Vaccine | 2013 | 8 Pages |
Abstract
⺠The environment alters the immune response to an intradermal (i.d.) TB subunit vaccine, Ad85A. ⺠Ad85A i.d. induces a lung immune response but is less protective against Mtb than intranasal Ad85A. ⺠Oral administration of environmental mycobacteria reduces Ad85A i.d induced protection. ⺠In vivo depletion of CD25+ regulatory T cells abolishes the effect of oral mycobacteria.
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Authors
Peter Beverley, Edward Ronan, Lianni Lee, Isabelle Arnold, Beatrice Bolinger, Fiona Powrie, Elma Tchilian,