Association of HLA class II genes with clinical hyporesponsiveness to trivalent inactivated influenza vaccine in children

► We examined if HLA genes are associated with clinical hyporesponsivness after TIV. ► Clinical hyporesponsiveness was occurrence of influenza illness in vaccinated children. ► HLA-DR7/4,DQB1*0302 was significant in non-Hispanic white children. ► HLA-DRB1*15 or 16 and HLA-DR7/Y were significant in Hispanic children. ► HLA class II genes are associated with clinical hyporesponsiveness to TIV.