Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10968541 | Vaccine | 2012 | 10 Pages |
Abstract
⺠Poly I:C-DOTAP Liposome Complex (PDLC) was prepared as a vaccine adjuvant. ⺠PDLC augmented vaccine-elicited CTL response and tumor regression. ⺠PDLC promoted bone-marrow dendritic cell (BMDC) maturation and type I IFN production. ⺠PDLC enhanced the recognition of poly I:C by TLR3 and downstream IRF3 phosphorylation in BMDCs.
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Authors
Ce Wang, Yan Zhuang, Yijuan Zhang, Zichao Luo, Ningning Gao, Ping Li, Hong Pan, Lintao Cai, Yifan Ma,