| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968580 | Vaccine | 2012 | 5 Pages |
Abstract
⺠New vaccines against serogroup B meningococcal disease are developed on the basis of variable protein antigens. ⺠Assessment of strain coverage requires genetic and phenotypical typing. ⺠Although the serum bactericidal assay is the golden standard to assess the susceptibility of a strain towards bactericidal antibodies, more convenient antigen expression assays are required for high throughput analysis. ⺠The MATS (meningococcal antigen typing system) is an example for assays assessing potential strain coverage to be used by national reference laboratories. ⺠The availability of MATS should be assured even after licensure; laboratory twinning is a strategy to generate a robust and reliable international database.
Keywords
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Immunology
Authors
Ulrich Vogel, Paola Stefanelli, Julio Vazquez, Muhamed-Kheir Taha, Heike Claus, John Donnelly,