| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968649 | Vaccine | 2013 | 7 Pages |
Abstract
⺠We produce a chimeric fusion protein incorporating selected Mycobacterium leprae antigens. ⺠We demonstrate protein recognition by IgG in MB leprosy patient sera. ⺠We demonstrate that fusion protein stimulates IFNγ production. ⺠We elicit a pluripotent Ag-specific Th1 response by including a TLR4L- adjuvant. ⺠We show immunization inhibits M. leprae-induced inflammation in mice.
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Authors
Malcolm S. Duthie, Lucas H. Sampaio, Regiane M. Oliveira, Vanitha S. Raman, Joanne O'Donnell, H. Remy Bailor, Greg C. Ireton, Ana Lucia M. Sousa, Mariane M.A. Stefani, Steven G. Reed,