Article ID Journal Published Year Pages File Type
10968718 Vaccine 2012 7 Pages PDF
Abstract
► Live attenuated nasopharyngeal S. pneumoniae exposure protects against invasive disease. ► Presence of capsule and lipoproteins during colonisation enhances immunogenicity and protection. ► Colonisation does not induce serum anti-capsular IgG. ► Duration/density of colonisation is important in determining immunogenicity of bacteria. ► Inclusion of capsule may enhance protective immunity of otherwise attenuated strains.
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Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation
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