| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969012 | Vaccine | 2012 | 11 Pages |
Abstract
⺠We examine four different Chiococca alba saponins containing 2, 3 and 4 sugar units. ⺠The best adjuvant potential was found in the four sugar units-saponin called CA4. ⺠CA4 was used for vaccination with the FML antigen of Leishmania donovani. ⺠CA4 induced a CD4+-TNF-α mediated protection against murine visceral leishmaniasis. ⺠Adjuvanticity increases with the length and hydrophilicity of saponins sugar chains.
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Authors
Dirlei Nico, Ricardo Moreira Borges, Layza Mendes Brandão, Daniel Ferreira Feijó, Daniele Crespo Gomes, Marcos Palatnik, Mauricio Martins Rodrigues, Antonio Jorge Ribeiro da Silva, Clarisa Beatriz Palatnik-de-Sousa,