Article ID Journal Published Year Pages File Type
10969013 Vaccine 2012 8 Pages PDF
Abstract
► Human yellow fever virus infection has no good mouse model. ► We developed an adult mouse model using AG129 mice and 17D-204 vaccine. ► AG129 mice are susceptible to 17D-204 in a dose-dependent manner. ► Virus infects both brain and liver. ► Biomarkers of inflammation suggest a biphasic liver infection similar to humans.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
A small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain
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