Trivalent influenza vaccine and febrile adverse events in Australia, 2010: Clinical features and potential mechanisms

Numerous febrile adverse events (including febrile seizures) were observed following Fluvax® or Fluvax Junior® in 2010. Clear differences in cytokine production were observed when peripheral blood mononuclear cells were stimulated with Fluvax® compared with alternate TIV preparations. Increased awareness of these potential adverse events is required to ensure earlier detection and prevention in the future.