Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10969045 | Vaccine | 2011 | 8 Pages |
Abstract
This randomized, double-blind study evaluated concomitant administration of 13-valent pneumococcal conjugate vaccine (PCV13) and trivalent inactivated influenza vaccine (TIV) in adults aged â¥65 years who were naïve to 23-valent pneumococcal polysaccharide vaccine. Patients (N = 1160) were randomized 1:1 to receive PCV13 + TIV followed by placebo, or Placebo + TIV followed by PCV13 at 0 and 1 months, with blood draws at 0, 1, and 2 months. Slightly lower pneumococcal serotype-specific anticapsular polysaccharide immunoglobulin G geometric mean concentrations were observed with PCV13 + TIV relative to PCV13. Concomitant PCV13 + TIV demonstrates acceptable immunogenicity and safety compared with either agent given alone.
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Authors
T.F. Schwarz, J. Flamaing, H.C. Rümke, J. Penzes, C. Juergens, A. Wenz, D. Jayawardene, P. Giardina, E.A. Emini, W.C. Gruber, B. Schmoele-Thoma,