| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969130 | Vaccine | 2011 | 10 Pages |
Abstract
In conclusion, novel VLPs expressing different HIV Env glycoproteins with native trimeric conformation have been generated, showing the induction of effective antibody response with neutralization activity in TZM-bl neutralization assay. These results confirm the effectiveness of VLPs as presentation and delivery system for conformational proteins and show the improved neutralization activity upon the combination of anti-sera elicited by different HIV envelope antigens, suggesting the possibility of broadening the spectrum of viral epitopes targeted by immune response.
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Authors
M.L. Visciano, L. Diomede, M. Tagliamonte, M.L. Tornesello, V. Asti, M. Bomsel, F.M. Buonaguro, L. Lopalco, L. Buonaguro,