Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10969307 | Vaccine | 2011 | 5 Pages |
Abstract
Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
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Authors
Mangala Rao, Kristina K. Peachman, Qin Li, Gary R. Matyas, Sathish B. Shivachandra, Richard Borschel, Venee I. Morthole, Carmen Fernandez-Prada, Carl R. Alving, Venigalla B. Rao,