| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969373 | Vaccine | 2011 | 14 Pages |
Abstract
⺠Meager meiotic recombination and single nucleotide polymorphisms affected genetic diversity at Pvama-1DII in Sri Lanka. ⺠Eleven a.a. variant positions defined 21 a.a. haplotypes with 9 unique to the island. ⺠Majority of Sri Lankan patients developed anti-AMA-1 antibodies to both conformational and linear B cell epitopes. ⺠The PvAMA-1DII loop was highly conserved in all local and global isolates. ⺠Highly immunogenic P04 peptide with protective antibody response is a strong contender for a vaccine construct.
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Authors
Sajani Dias, Maheshika Somarathna, Aresha Manamperi, Ananias A. Escalante, Anusha M. Gunasekera, Preethi V. Udagama,