Article ID Journal Published Year Pages File Type
10969394 Vaccine 2012 6 Pages PDF
Abstract
► We generated rotavirus subunit ΔVP8* vaccine with P[8], P[6] or P[4] specificity. ► Each ΔVP8* protein was highly soluble and was generated in high yield in E. coli. ► Each ΔVP8* protein induced high levels of neutralizing antibodies in guinea pigs. ► These ΔVP8* parenteral vaccines may be more effective in low-income countries.
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Related Topics
Life Sciences Immunology and Microbiology Immunology
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Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates
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