| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969415 | Vaccine | 2012 | 9 Pages |
Abstract
⺠Lymphocytes, or their supernatants induce maturation and type-1 polarization of DCs. ⺠Lymphocyte-matured DC1s produce IL-12p70 and CXCL10 upon subsequent CD40 ligation. ⺠Lymphocyte-matured DC1s showed enhanced CCR7 expression and migration to CCL21. ⺠Lymphocyte-matured DC1s induce CTLs against tumor-associated antigens. ⺠TNFα/IFNγ-secreting T cells limit the need for DC1-polarizing cytokines.
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Authors
Erik Berk, Ravikumar Muthuswamy, Pawel Kalinski,