| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969434 | Vaccine | 2011 | 10 Pages |
Abstract
⺠We analyzed in vivo gene expression data from both the bovine host and the zoonotic bacterial pathogens. ⺠We developed computational systems biology models of the host-pathogen interactions. ⺠We applied Dynamic Bayesian Network machine learning to identify pathogenicity biosignatures. ⺠The systems biology analysis identified significant biosignature mechanistic genes as deletion targets for enhanced rational design and attenuation of live vaccine candidates.
Keywords
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Immunology and Microbiology
Immunology
Authors
L. Garry Adams, Sangeeta Khare, Sara D. Lawhon, Carlos A. Rossetti, Harris A. Lewin, Mary S. Lipton, Joshua E. Turse, Dennis C. Wylie, Yu Bai, Kenneth L. Drake,