| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969488 | Vaccine | 2012 | 10 Pages |
Abstract
⺠We designed a structure of dendritic tandem multiple hTERT antigenic peptides. ⺠We isolated myeloid dendritic cells and homologous T lymphocytes. ⺠Activation effects of homologous T lymphocytes agitated by MDC loaded with MAP were tested. ⺠Killing effect of activated T cells on corresponding tumor cells were detected. ⺠MAP combined MDC has the potential to become a powerful broad-spectrum anti-tumor vaccine.
Keywords
granulocyte-macrophage CSFTNFTelomeres and telomeraseFBSMLCPBMCCTLMACSGM-CSFAPCBSAbovine serum albuminHLAEpitopesCellular immunotherapyinterferonIFNC-terminalfetal bovine serumPeripheral blood mononuclear cellDendritic cellsCytotoxicitytumor necrosis factorMixed lymphocyte culturecytotoxic T lymphocyteMHCmajor histocompatibility complexmagnetic-activated cell sortingCancer vaccineAntibodycarboxy-terminal
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Authors
Bai-lin Niu, Hui-min Du, Hua-ping Shen, Zheng-rong Lian, Jin-zheng Li, Xing Lai, Si-dong Wei, Li-quan Zou, Jian-ping Gong,