| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969490 | Vaccine | 2012 | 8 Pages |
Abstract
⺠Fusion conjugates are protein-TLR agonist fusions coupled to polysaccharides (PS). ⺠Salmonella typhi Vi PS and pneumococcal wall PS were coupled to pneumococcal fusions. ⺠High-titer Vi antibody opsonic to S. typhi was elicited in mice. ⺠The induced IL17 and antibody prevented murine pneumococcal colonization and sepsis. ⺠This bivalent combination may immunize infants vs. typhoid and pneumococcal diseases.
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Authors
Ying-Jie Lu, Fan Zhang, Sabina Sayeed, Claudette M. Thompson, Shousun Szu, Porter W. Anderson, Richard Malley,