| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969495 | Vaccine | 2012 | 10 Pages |
Abstract
⺠Sortase forms a single covalent bond between a carrier protein and a capsule antigen. ⺠PDGA-D4 vaccine includes polyglutamate and the D4 domain of protective antigen. ⺠PDGA-D4 elicits immunity against Bacillus anthracis challenge in guinea pigs. ⺠PDGA-D4 elicits immunity against pagA mutant Bacillus anthracis. ⺠Sortase-conjugation may be broadly useful to generate conjugate vaccines.
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Authors
Gabriella Garufi, Ya-Ting Wang, So-Young Oh, Hannah Maier, Dominique M. Missiakas, Olaf Schneewind,