| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969612 | Vaccine | 2012 | 10 Pages |
Abstract
⺠We evaluated the immunogenicity of VZV glycoprotein E-based herpes zoster vaccines. ⺠Mice were immunized with gE combined with saline, Al salt or an Adjuvant System. ⺠Adjuvant Systems AS01 and AS02 contain the immunostimulants QS21 and MPL. ⺠gE formulated with an Adjuvant System elicited higher CD4+ T cell responses than other vaccines. ⺠gE formulated with AS01B induced higher CMI responses compared to other gE/AS01 formulations, supporting clinical evaluation.
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Authors
Najoua Dendouga, Michel Fochesato, Laurence Lockman, Sally Mossman, Sandra L. Giannini,