| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969623 | Vaccine | 2012 | 6 Pages |
Abstract
⺠Hepatitis antigens expressed in maize can provide a commercially feasible oral vaccine. ⺠Elevated levels of HBsAg were achieved in maize seed with embryo-preferred promoters. ⺠Optimization of genetic background and processing resulted in high HBsAg levels. ⺠Mice displayed robust systemic and mucosal immune responses after oral boosting. ⺠Immunogenicity of the material was not adjuvant-dependent.
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Authors
Celine A. Hayden, Stephen J. Streatfield, Barry J. Lamphear, Gina M. Fake, Todd K. Keener, John H. Walker, John D. Clements, Debra D. Turner, Ian R. Tizard, John A. Howard,