| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969630 | Vaccine | 2012 | 8 Pages |
Abstract
⺠Artificial ribonucleases (aRNases) do inactivate the influenza A virus. ⺠The most active 3 aRNases display low cytotoxicity. ⺠These aRNases affect minimally the affinity of monoclonal antibodies for viral particles. ⺠The aRNases cause degradation of viral RNA. ⺠A high protective activity of the aRNase-inactivated virus as a vaccine was demonstrated.
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Authors
Antonina A. Fedorova, Elena P. Goncharova, Mikhail P. Kovpak, Valentin V. Vlassov, Marina A. Zenkova,