Article ID Journal Published Year Pages File Type
10969632 Vaccine 2012 8 Pages PDF
Abstract
► We studied the immunogenicity and stability a pneumococcal vaccine in Al adjuvants. ► Immunogenicity was significantly higher in AlO(OH) compared to AlPO4. ► Lower microenvironment pH improved the stability of the vaccine. ► Optimal immunogenicity of the trivalent vaccine was obtained with 28 μg Al/dose. ► Pretreatment of the aluminum hydroxide with phosphate improved stability.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
Formulation, stability and immunogenicity of a trivalent pneumococcal protein vaccine formulated with aluminum salt adjuvants
Authors
, , , , , , ,