| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969641 | Vaccine | 2012 | 8 Pages |
Abstract
⺠LAIV nasal vaccination in ferrets using a high efficiency nebulizer was investigated. ⺠LAIV was effectively delivered to the upper airways and was immunogenic after aerosol delivery. ⺠Despite the failure to isolate virus there was induction of protective levels of serum antibodies. ⺠Aerosol vaccination was protective against homologous challenge in ferrets. ⺠Aerosol vaccination decreased the length and amount of virus shed after heterotypic challenge.
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Authors
Jennifer Humberd Smith, Mark Papania, Darin Knaus, Paula Brooks, Debra L. Haas, Raydel Mair, James Barry, S. Mark Tompkins, Ralph A. Tripp,