Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10969674 | Vaccine | 2010 | 7 Pages |
Abstract
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10Â mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000Â mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
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Authors
Nishaki Mehta, Coleen K. Cunningham, Patricia Flynn, Joyce Pepe, Stephen Obaro, Bill G. Kapogiannis, James Bethel, Katherine Luzuriaga, Adolescent Trials Network for HIV/AIDS Interventions Adolescent Trials Network for HIV/AIDS Interventions,