| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969724 | Vaccine | 2012 | 8 Pages |
Abstract
⺠Antibodies against the DBL4É-ID4 subunit of the VAR2CSA protein can inhibit parasite binding to the placental ligand chondroitin sulphate A. ⺠We tested the ability of DBL4É-ID4 to induce binding-inhibitory antibodies when formulated with adjuvants approved for human use. ⺠We have characterized the immune response of DBL4É-ID4 in combination with Freund's adjuvant, Montanide® ISA 720, Alhydrogel® and CAF01. ⺠The results demonstrate that the DBL4É-ID4 antigen is highly immunogenic and that binding inhibitory antibodies are induced when formulated with any of the tested adjuvants.
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Immunology
Authors
V.V. Pinto, A. Salanti, L.M. Joergensen, M. Dahlbäck, M. Resende, S.B. Ditlev, E.M. Agger, D.E. Arnot, T.G. Theander, M.A. Nielsen,