| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969726 | Vaccine | 2012 | 8 Pages |
Abstract
⺠In this study we have evaluated the immunogenicity of PLGA microspheres encapsulating BSA and different immunostimulatory adjuvants. ⺠Microspheres sized around 1 μm and released the peptide showing the typical triphasic profile. ⺠All the microspheres developed high antibody responses, which were IgG1/IgG2a balanced, when administered to Balb/c mice. ⺠Only combination of MPLA and α-galactosylceramide within the microspheres increased the cellular immune response.
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Authors
Aiala Salvador, Manoli Igartua, Rosa Mª Hernández, José Luis Pedraz,