| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969776 | Vaccine | 2011 | 10 Pages |
Abstract
⺠We determine if protective immunity against influenza A viruses is higher in females than males. ⺠We examine humoral immune responses to primary sublethal infection with H1N1 or H3N2 viruses and virus titers and morbidity following secondary lethal challenge with homologous or heterologous virus. ⺠Females mount higher neutralizing and total anti-influenza A virus antibodies and experience less morbidity and have lower viral titers in their lungs after infection with a lethal dose of heterologous virus. ⺠Females develop greater cross protection against influenza A viruses than males.
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Authors
Maria E. Lorenzo, Andrea Hodgson, Dionne P. Robinson, Jenifer B. Kaplan, Andrew Pekosz, Sabra L. Klein,