Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10969799 | Vaccine | 2011 | 7 Pages |
Abstract
⺠Hypothesis that mRNA molecules can have potent adjuvant effects in DNA vaccination was tested in vitro and in mice. ⺠RNA CpG and dsRNA motifs were incorporated into the transcribed region of pVAX1 DNA expressing M. leprae hsp65. ⺠Inserted immunostimulatory motifs resulted in substantially enhanced Th1 and cellular immune responses in mice. ⺠Inserted immunostimulatory motifs also enhanced significantly the therapeutic effect of DNA vaccine in mice that had been infected by aerosol with H37Rv.
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Authors
Juan Wu, Hui Ma, Qing Qu, Wen-Jiang Zhou, Yu-Ping Luo, Harry Thangaraj, Dougtas B. Lowrie, Xiao-Yong Fan,