| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969808 | Vaccine | 2011 | 8 Pages |
Abstract
⺠A P particle-M2e chimeric vaccine was generated by insertion of human influenza A M2e epitope into norovirus P particle. ⺠Mice developed significantly increased IgG against M2e after immunization with this chimeric vaccine and 100% survived from a lethal challenge with influenza virus. ⺠Antibodies induced by the chimeric vaccine blocked norovirus VLP and P particle binding to HBGA receptors, suggesting an opportunity to develop a dual vaccine against both influenza and noroviruses.
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Authors
Ming Xia, Ming Tan, Chao Wei, Weiming Zhong, Leyi Wang, Monica McNeal, Xi Jiang,