| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10969811 | Vaccine | 2011 | 8 Pages |
Abstract
⺠High dose vaccination with HCR/A protected mice from challenge by heterologous BoNT/A subtypes. ⺠Low dose HCR/A vaccination yielded partial protection to heterologous BoNT/A subtype challenge. ⺠Vaccination with HCR/A1 elicited an A1 subtype-specific IgG response. ⺠Survival to heterologous BoNT/A2 challenge with HCR/A1 vaccination correlated with IgG to the denatured HCRc/A1. ⺠Survival to heterologous BoNT/A1 challenge with HCR/A2 vaccination correlated with IgG titers to native HCRc/A1.
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Authors
James S. Henkel, William H. Tepp, Amanda Przedpelski, Robert B. Fritz, Eric A. Johnson, Joseph T. Barbieri,