Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10970071 | Vaccine | 2010 | 9 Pages |
Abstract
Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p < 0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group.
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Authors
F.M. Russell, P.V. Licciardi, A. Balloch, V. Biaukula, L. Tikoduadua, J.R. Carapetis, J. Nelson, A.W.J. Jenney, L. Waqatakirewa, S. Colquhoun, Y.B. Cheung, M.L.K. Tang, E.K. Mulholland,