Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10970105 | Vaccine | 2009 | 8 Pages |
Abstract
Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates.
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Authors
Thi Kim Anh Nguyen, Ad P. Koets, Wiebren J. Santema, Willem van Eden, Victor P.M.G. Rutten, Ildiko Van Rhijn,