Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10970353 | Vaccine | 2008 | 9 Pages |
Abstract
Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (ALÂ +Â EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.
Keywords
KLHphorbol 12-myristate 13-acetateTregDTHAPCOVAHSV-1MLRConcanavalin AmAbKeyhole-limpet hemocyaninnatural killerPMAantigen-presenting cellOvalbuminadaptive immunityinterleukinCon Atumor necrosis factor alphaCell proliferationDelayed type hypersensitivityRegulatory T cellCytokinesstimulation indexURTIUpper respiratory tract infectionTNF-αLymphotactinHerpes simplex virus-1Monoclonal antibodiesmixed lymphocyte responsekilometer
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Authors
Connie J. Rogers, David A. Zaharoff, Kenneth W. Hance, Susan N. Perkins, Stephen D. Hursting, Jeffrey Schlom, John W. Greiner,