Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10970426 | Vaccine | 2008 | 8 Pages |
Abstract
Complement, complement receptors and natural antibody (IgM) are important factors in the immune response against pathogens. Previous studies have indicated a role for C3, the complement receptors CD35/CD21 (CR1/CR2), and IgM in the immune response to influenza virus. Nevertheless, their contribution to the long-term memory response to this pathogen remains unknown. To elucidate this role, we characterized the secondary response on mice deficient of CR1/CR2 (Cr2â/â), C3 (C3â/â), secreted IgM (μsâ/â) and the double knockout C3â/âμsâ/â. Overall, our results suggest that C3, IgM and CR1/CR2 play crucial roles in the maintenance of long-term memory to influenza virus, possibly through the development of memory B cells and long-term antibody secretion.
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Authors
Santiago Fernandez Gonzalez, Jerome Priyantha Jayasekera, Michael C. Carroll,