| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10970428 | Vaccine | 2008 | 8 Pages |
Abstract
The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.
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Authors
Panisadee Avirutnan, Erin Mehlhop, Michael S. Diamond,