Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10970481 | Vaccine | 2007 | 9 Pages |
Abstract
The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.
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Immunology
Authors
Marisela Hernández, José Luis Cabrera-Ponce, Gladis Fragoso, Fernando López-Casillas, Arturo Guevara-GarcÃa, Gabriela Rosas, Claudia León-RamÃrez, Patricia Juárez, Guadalupe Sánchez-GarcÃa, Jaquelynne Cervantes, Gonzalo Acero, Andrea Toledo,