Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10970509 | Vaccine | 2007 | 8 Pages |
Abstract
Persistence of antibodies following a single dose of Tdap vaccine (tetanus, diphtheria, and five-component acellular pertussis vaccine for use in individuals past childhood) was evaluated in a follow-up of adolescents (NÂ =Â 324) and adults (NÂ =Â 644) who had received Tdap in earlier clinical trials. Outcome measures were seroprotection (tetanus and diphtheria) or seropositivity (pertussis) and geometric mean titers. Humoral immune responses to all antigens were robust 1 month after initial immunization; antibodies exceeded pre-immunization levels 1, 3, and 5 years later. These data will contribute to selecting the optimal interval for booster doses of Tdap.
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Authors
L. Barreto, R. Guasparini, W. Meekison, F. Noya, L. Young, E. Mills,