Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10971425 | Developmental & Comparative Immunology | 2015 | 9 Pages |
Abstract
Porcine ileum is populated with a high proportion of B cells but previous studies have shown that they are not developed there. While B cells prevail in the ileum even in germ-free animals, microbial colonization is a major factor that causes even a greater prevalence of B cells in the ileum and further differential representation of lymphoid cells throughout small intestine. Analysis of lymphoid subpopulations showed that the effector cells appear only after colonization. These include class-switched IgM+IgA+ B cells, primed CD2-CD21+ B cells, antibody-producing/memory CD2+CD21- B cells, and effector/memory CD4+CD8+ αβ Th cells. While colonization resulted in a uniform distribution of effector cells throughout the gut, it caused a decrease in the frequency of cytotoxic αβ and CD2+CD8+ γδ T cells. These results suggest that the ileum is a site where naive B cells expand presumably to increase antibody repertoire but the entire small intestine is immunofunctionally comparable.
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Authors
Hana Potockova, Jana Sinkorova, Kristyna Karova, Marek Sinkora,