| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10971647 | Developmental & Comparative Immunology | 2012 | 10 Pages |
Abstract
⺠Japanese flounder type I IFN gene was cloned and clustered with Acanthopterygii. ⺠The poly I:C-responsible region (â634 to â179 bp) was found in IFN promoter. ⺠Transcriptional activity of IFN promoter was enhanced by the flounder IRF3. ⺠The activity of IFN promoter was induced by RLRs after poly I:C-stimulation.
Keywords
TBK1IFN-stimulated gene factor 3IKKεDouble-strand RNApolyriboinosinic:polyribocytidylic acidLGP2ISGF3RLRISREMDA5RIG-IIRF3IRFdsRNACpG-ODNTLRATF2JAK/STATBACNFκBlaboratory of genetics and physiology 2STATInnate immunityinterferonType I interferonIFNToll-like receptorinterferon regulatory factorinterferon-stimulated response elementNuclear factor-kappa Bactivating transcription factor 2Signal transducer and activator of transcriptionPoly I:Cmelanoma differentiation-associated gene 5retinoic acid-inducible gene-Ijanus kinase/signal transducer and activator of transcriptionRIG-I-like receptor
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Authors
Maki Ohtani, Jun-ichi Hikima, Seong Don Hwang, Takahiro Morita, Yoshiaki Suzuki, Goshi Kato, Hidehiro Kondo, Ikuo Hirono, Tae-Sung Jung, Takashi Aoki,