Article ID Journal Published Year Pages File Type
10971653 Developmental & Comparative Immunology 2012 5 Pages PDF
Abstract
► Chicken TLR3 and TLR21 recognize poly I:C and CpG-ODN. ► Poly I:C and CpG-ODN induce a differential expression of IFN-α, IFN-β, IFN-γ, IL-4, IL-10, and IL-12 in chicken monocytes. ► Co-stimulation with poly I:C and CpG-ODN synergistically up-regulates the expression of IFN-γ and IL-10. ► CpG-ODN and the synergy between poly I:C and CpG-ODN promote Th1-biased immune response.
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Co-stimulation with TLR3 and TLR21 ligands synergistically up-regulates Th1-cytokine IFN-γ and regulatory cytokine IL-10 expression in chicken monocytes
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