| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10971719 | Developmental & Comparative Immunology | 2012 | 10 Pages |
Abstract
⺠We cloned the Japanese flounder TLR3 (JfTLR3) gene. ⺠Gene expression of JfTLR3 was up-regulated in PBLs after stimulation with poly I:C and CpG ODN 1668. ⺠JfTLR3 gene was induced in different tissues following infection with VHSV. ⺠Intracellular poly I:C in JfTLR3-overexpressing YO-K cells activates IFN and NF-κB pathways. ⺠In JfTLR3-overexpressing HINAE cells, extracellular poly I:C activates IFN and NF-κB pathways.
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Authors
Seong Don Hwang, Maki Ohtani, Jun-ichi Hikima, Tae Sung Jung, Hidehiro Kondo, Ikuo Hirono, Takashi Aoki,