Atlantic halibut experimentally infected with nodavirus shows increased levels of T-cell marker and IFNγ transcripts

► Viral RNAs were increasing in brain and eye during the 14 weeks post injection. ► An increase in the levels of IL-1β and IL-6 were seen early in the halibut brain. ► An increase in the levels of IFNγ was seen later in the halibut brain and eye. ► An involvement of halibut T-cells against nodavirus could be suggested. ► ISG15 and MX were elevated in brain, eye and kidney at different time points.